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To read the full abstract: N Engl J Med 2018;378:1302-1312.While it is well known that being overweight in childhood and early adulthood is linked to a higher risk of T2DM later in life, the question arises as to whether diabetes risk would change if overweight children lose weight. This large-scale longitudinal study demonstrated that men who had remission of overweight between ages 7 and 13 yea...

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ey0018.11-5 | New hope: Increased diagnostic yield for disease causing MC4R variants and pharmacological treatment options | ESPEYB18

11.5. Obesity treatment effect in danish children and adolescents carrying melanocortin-4 receptor mutations

C Trier , M Hollensted , TM Schnurr , MAV Lund , TRH Nielsen , G Rui , EA Andersson , M Svendstrup , DS Bille , AP Gjesing , CE Fonvig , C Frithioff-Bojsoe , M Balslev-Harder , S Quan , M Gamborg , O Pedersen , L Angquist , JC Holm , T Hansen

Int J Obes (Lond). 2021;45(1):66–76. doi: https://doi.org/10.1038/s41366-020-00673-6This study investigated the influence of MC4R variants on treatment effectiveness in a large cohort undergoing an outpatient treatment program. Carriers of MC4R loss-of-function (LoF) variants showed a lack of improvement in BMI, in contrast to non LoF carriers.As we learn th...

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ESPE Yearbook of Paediatric Endocrinology

12.1 Change in Overweight from Childhood to Early Adulthood and Risk of Type 2 Diabetes

11.5. Obesity treatment effect in danish children and adolescents carrying melanocortin-4 receptor mutations

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